Figure 5.

Combination roles of GABA_A- and GABA_B-mediated inhibitions in the TRN-SRN pathway in controlling absence seizures. The distributions of dynamical states (A) and dominant frequency (B) in the two-parameter space ($-v_{sr}^B,-v_{sr}^A$). Similar to the results in Figure 2A, there are four dynamical states in this two-parameter space, the regions of the typical 2–4 Hz SWDs indicated with asterisk (“*”) are surrounded by black dashed lines. (C) State analysis of ϕ_e as a function of the scale factor K, defined as the relative strength of GABA_B and GABA_A inhibitions in the TRN-SRN pathway. The gray region describes the region of typical 2–4 Hz SWDs, and the dashed green lines are used to show the demarcations of different dynamical states in the control process of absence seizures.