Fig. 5.

Phenotypes of HFD-fed WNK4^−/− mice. (a–c) IPGTT (a), plasma insulin levels (b), IPITT (c), and their AUCs in HFD-fed WT and WNK4^−/− mice. The HFD-fed WNK4^−/− mice showed lower fasting glucose levels and presented lower plasma glucose levels 15 min after glucose injection (n = 5 per group; a). Plasma insulin level and AUC result during the glucose tolerance test (n = 5 per group; c). WNK4^−/− mice exhibited significantly lower AUC values (n = 5–6 per group). (d–g) Fasting plasma triglyceride (d), total cholesterol (e), adiponectin (f), and leptin levels (g) were not affected in the WNK4^−/− mice (n = 5–6). Values are expressed as mean ± 95%CI. *P < 0.05.