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. 2017 Mar 14;18:179–187. doi: 10.1016/j.ebiom.2017.03.021

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© 2017 The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 6 — Piperine acted as an agonist of peroxisome proliferator activated receptor-γ (PPAR-γ). (a) The effect of piperine on Ppar-γ transactivation in mouse adult CFs (n = 6). (b) The mRNA level of Ppar-γ in mouse adult CFs (n = 6). (c) The mRNA level of α-Sma in mouse adult CFs after GW9662 treatment (n = 6). (d–f) Alterations in the AKT/GSK3β pathway after GW9662 treatment in mouse adult CFs (n = 6). Values represent the mean ± SEM. ^⁎P < 0.05 versus the matched control. NS; no significance. Veh, vehicle; PIO, pioglitazone.