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Schematic diagram of SRT1720 action.
SRT1720 improves glucose homeostasis and protects against metabolic disorders by activating AMPK and Sirt1 via interlinked pathways. Although we were not able to confirm the role of the PKA-LKB1 pathway in SRT1720 effect, the PKA-LKB1 link has been reported previously (Shelly et al., 2007).
