Table 2.
Discovery and replication cohorts: clinical characteristics according to the absence or presence of LVH.
| Characteristic | Discovery cohort |
Replication cohort |
||||||
|---|---|---|---|---|---|---|---|---|
| All patients | No LVH | LVH | P value | All patients | No LVH | LVH | P value | |
| n | 318 | 205 | 113 | 5631 | 4071 | 1560 | ||
| Age (years) | 63.9 ± 11.7 | 61.9 ± 12.0 | 67.7 ± 10·4 | < 0.0001 | 65.5 ± 11·0 | 64.7 ± 11.4 | 67.6 ± 9.6 | < 0.0001 |
| Male gender, n (%) | 172 (54) | 127 (62) | 45 (40) | < 0.0001 | 3106 (55.2) | 2268 (55.7) | 838 (53.7) | 0.19 |
| Diabetes duration (year)a | 10 [5, 16] | 10 [5, 16] | 12 [6, 18] | 0.05 | 5.2 [2.7, 9.6] | 5.1 [2.6, 9.4] | 5.6 [2.8, 10.2] | 0.002 |
| BMI (kg/m2) | 31.7 ± 6.1 | 31.7 ± 5.8 | 31.7 ± 6.5 | 0.99 | 31.0 ± 5.7 | 30.9 ± 5.7 | 31.0 ± 5.4 | 0.56 |
| HbA1c (%) | 7.7 ± 1.3 | 7.6 ± 1.3 | 7.9 ± 1.2 | 0.06 | 7.4 ± 1.1 | 7.4 ± 1.1 | 7.4 ± 1.1 | 0.33 |
| eGFR (ml/min/1.73m2) | 71 ± 21 | 73 ± 20 | 68 ± 22 | 0.08 | 71% ≥ 60 | 77% ≥ 60 | 55% ≥ 60 | < 0.0001 |
| Systolic blood pressure (mm Hg) | 138 ± 20 | 136 ± 19 | 141 ± 21 | 0.03 | 140 ± 11 | 140 ± 10 | 141 ± 12 | 0.0055 |
| Diastolic blood pressure (mm Hg) | 76 ± 10 | 76 ± 10 | 75 ± 9 | 0.36 | 78 ± 6.3 | 78 ± 6.1 | 77 ± 6.6 | < 0.0001 |
| Hypertension, n (%) | 250 (79) | 157 (77) | 93 (82) | 0.23 | – | – | – | – |
| Oral hypoglycaemics and/or insulin, n (%) | 288 (91) | 189 (92) | 99 (88) | 0·18 | 4893 (86.9) | 3537 (86.9) | 1356 (86.9) | 1.00 |
Data is expressed as mean ± SD.
a
Median [25th, 75th quartiles] or n (%). BMI, body mass index; eGFR, estimated glomerular filtration rate.