Table 4.
Discovery cohort: relationship between KLF15 SNP genotypes and echocardiographic parameters.
| Genotypes |
P values for dominant model |
||||
|---|---|---|---|---|---|
| Unadjusted | Adjusteda | ||||
| KLF15 rs9838915 | GG | GA | AA | ||
| n | 235 | 72 | 11 | ||
| LVMI (g/m2) | 95.9 ± 25.5 | 105.3 ± 28.8 | 109.3 ± 25.9 | 0.003 | 0.001 |
| Posterior wall thickness (cm) | 1.04 ± 0.15 | 1.08 ± 0.15 | 1.07 ± 0.13 | 0.032 | 0.004 |
| Septal wall thickness (cm) | 1.05 ± 0.15 | 1.11 ± 0.14 | 1.08 ± 0.16 | 0.003 | < 0.0001 |
| LVEDD (cm) | 4.9 ± 0.7 | 4.9 ± 0.7 | 5.1 ± 0.5 | 0.69 | 0.96 |
| LVESD (cm) | 3.1 ± 0.8 | 3.2 ± 0.8 | 3.1 ± 0.4 | 0.96 | 0.11 |
| Ejection fraction (%) | 68 ± 11 | 68 ± 12 | 69 ± 9 | 0.59 | 0.28 |
| KLF15 rs6796325 | TT | TC | CC | ||
| n | 165 | 123 | 30 | ||
| LVMI (g/m2) | 97.6 ± 25.6 | 101.3 ± 27.8 | 95.0 ± 27.0 | 0.34 | 0.69 |
| Posterior wall thickness (cm) | 1.04 ± 0.14 | 1.06 ± 0.16 | 1.03 ± 0.15 | 0.69 | 0.34 |
| Septal wall thickness (cm) | 1.06 ± 0.15 | 1.08 ± 0.16 | 1.06 ± 0.13 | 0.52 | 0.60 |
| LVEDD (cm) | 4.9 ± 0.8 | 4.9 ± 0.7 | 4.9 ± 0.9 | 0.31 | 0.27 |
| LVESD (cm) | 3.1 ± 0.8 | 3.1 ± 0.8 | 3.4 ± 0.8 | 0.40 | 0.44 |
| Ejection fraction (%) | 68 ± 11 | 69 ± 12 | 66 ± 16 | 0.83 | 0.28 |
Data is expressed as mean ± standard deviation.
a
Adjusted for known risk factors for increased LV mass (age, gender, BMI, hypertension). LVEDD, left ventricular end diastolic dimension; LVESD, left ventricular end systolic dimension; LVMI, left ventricular mass index.