Table 5.
Discovery cohort.
| A. Cox regression analysis of independent predictors of incident heart failure hospitalization according to the presence of LVH adjusted for known predictors of heart failure | ||
|---|---|---|
| Variables | HR (95% CI) | P value |
| Presence of LVH | 3.0 (1.1–7.9) | 0.029 |
| Age (years) | 1.1 (1.0–1.1) | 0.006 |
| Male gender | 2.5 (0.9–7.2) | 0.084 |
| BMI (kg/m2) | 1.1 (1.0–1.2) | 0.003 |
| Systolic blood pressure (mmHg) | 1.0 (0.9–1.0) | 0.504 |
| Hypertension | 2.4 (0.3–21.2) | 0.416 |
| B: Cox regression analysis of independent predictors of heart failure according to the presence of LVH stratified by KLF15 rs9838915 genotype adjusted for known predictors of heart failure | ||
|---|---|---|
| Variables | HR (95% CI) | P value |
| No LVH and GA/AA genotypea | 1.9 (0.4–9.8) | 0.462 |
| LVH and GG genotypea | 2.4 (0.7–8.4) | 0.165 |
| LVH and GA/AA genotypea | 5.5 (1.6–18.6) | 0.006 |
| LVH and GA/AA genotypeb | 3.3 (1.2–9.2) | 0.020 |
| Age (years) | 1.1 (1.0–1.1) | 0.005 |
| Male gender | 2.4 (0.9–6.9) | 0.098 |
| BMI (kg/m2) | 1.1 (1.0–1.2) | 0.004 |
| Systolic blood pressure (mm Hg) | 1.0 (0.9–1.0) | 0.458 |
| Hypertension | 3.2 (0.3–30.6) | 0.313 |
LVH, left ventricular hypertrophy; BMI, body mass index.
a
Hazard ratio compared to no LVH and GG genotype.
b
Hazard ratio compared to patients with LVH and GG genotype.