Table 6.
Replication cohort.
| A. Genotype distribution by LVH | |||||
|---|---|---|---|---|---|
| KLF15 SNP | Allele | Case | Control | Total | P value |
| rs9838915 | GG | 985 (26.8%) | 2688 (73.2%) | 3673 | 0.049 |
| GA | 483 (28.6%) | 1208 (71.4%) | 1691 | ||
| AA | 60 (34.5%) | 114 (65.5%) | 174 | ||
| Total | 1528 (27.6%) | 4010 (72.4%) | 5538 | ||
| rs6796325 | TT | 939 (28.1%) | 2399 (71.9%) | 3338 | 0.54 |
| TC | 537 (27.4%) | 1422 (72.6%) | 1959 | ||
| CC | 72 (25.3%) | 213 (74.7%) | 285 | ||
| Total | 1548 (27.7%) | 4034 (72.3%) | 5582 | ||
| B: Logistic regression analyses for LVH with SNP rs9838915 | |||
|---|---|---|---|
| Estimate | Std. Error | P value | |
| rs9838915 GA | 0.06783 | 0.06824 | 0.32 |
| rs9838915 AA | 0.38727 | 0.17054 | 0.023 |
| Male gender | 0.17931 | 0.06840 | 0.008 |
| Age (years) | 0.01095 | 0.00373 | 0.003 |
| BMI (kg/m2) | 0.02742 | 0.00612 | < 0.0001 |
| Systolic blood pressure (mm Hg) | − 0·14612 | 0.02785 | < 0.0001 |
| Diastolic blood pressure (mmHg) | − 0.33324 | 0.05179 | < 0.0001 |