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. 2017 Mar 31;18:311–319. doi: 10.1016/j.ebiom.2017.03.043

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© 2017 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 3 — A: Plasma corticosterone levels of control (male CTR, n = 6; female CTR, n = 12) rats and chronic unpredictable mild stress (CUMS) rats (male CUMS, n = 6; female CUMS, n = 12). B: Hypocretin (Hcrt) receptor-1-mRNA expression in frontal cortex of CTR and CUMS rats. Please note that female CUMS rats (n = 12) had significantly higher Hcrt receptor-1-mRNA levels compared with female controls (n = 12). C: There was a significant positive correlation between prepro-hypocretin-mRNA and corticotropin-releasing hormone (CRH)-mRNA in the hypothalamus of female CUMS rats (rho = 0·775, p = 0·007, n = 12). D: There was no significant correlation between prepro-hypocretin-mRNA and CRH-mRNA in the hypothalamus of male CUMS rats (rho = − 0·238, p = 0·517, n = 6).