Table 1.
Clinico-pathological information of subjects for hypothalamus study.
| NBB | Group | Sex | Age at death/age of onset (y) | PMD (hr:min) | FT (d) | CTD | MOD | CSF pH | BW (g) | Braak stage | Medication in the past | Medication in the last 3 months | Suicide thought | Suicide attempt | Cause of death |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 92-003 | MDD | F | 55/2 | 4:54 | 52 | 07:45 | 11 | 6.40 | 1320 | ND | BZD, SSRI, TeCA | SSRI, BZD, bromocriptine | Yes | Yes | Suspected urosepsis, heart failure |
| 94-032 | MDD | M | 71/2 | 16:15 | 38 | 16:15 | 2 | ND | 975 | ND | ZUC, BZD, MAOI, digoxine | None | Yes | Yes | Probably broncho-pnemonia, next to cerebral ischaemia |
| 94-017 | MDD | F | 72/20 | 22:00 | 39 | 19:00 | 1 | ND | 1287 | ND | TeCA, BZD, prednison | None | NO | No | Bronchopneumonia, mesothelioma |
| 12-097 | MDD | F | 73/9 | 5:45 | 61 | 15:30 | 9 | 6.70 | 1205 | ND | TeCA | TCA, TeCA, BZD, pancuronium, Ba | No | No | Heart failure, legal euthanasia |
| 95-036 | MDD | M | 74/0.5 | 62 | 35 | 17:05 | 3 | ND | 1444 | ND | SSRI, BZD, cisordinol | SSRI, BZD, cisordinol | Yes | Yes | Suicide by hanging |
| 02-051 | MDD | M | 81/34 | 15:30 | 34 | 15:30 | 6 | 6.50 | 1345 | 3 | None | Hal | No | No | Renal insufficiency |
| 11-058a | MDD | M | 83/24 | 10:40 | 57 | 05:00 | 7 | 6.50 | 1200 | 2 | TCA, TeCA, Hal, Pipamperon, SSRI | BZD, gabapentin, clonazepam, Mo | No | No | PTSS with depression, acute heart failure |
| 08-076 | MDD | F | 91/36 | 5:20 | 36 | 09:05 | 8 | 6.53 | 1163 | 3 | Hal, SSRI, BZD, levothyroxine | SSRI, BZD, levothyroxine | No | No | Cachexia and dehydration by pneumonia and renal insufficiency |
| 08-031 | MDD | F | 93/63 | 4:20 | 51 | 04:55 | 3 | 6.80 | 1023 | 2 | SSRI, BZD | Mo, BZD, SSRI | Yes | Yes | Pneumonia |
| 02-014 | BD | M | 68/26 | 12:00 | 30 | 00:00 | 2 | 6.64 | 1424 | 1 | Li, Hal, ZUC, MAOI | MAOI | No | No | Subdural hematoma |
| 99–118 | BD | M | 68/30 | 5:55 | 33 | 23:15 | 10 | 6.82 | 1204 | 1 | Li, SSRI | Li | Yes | No | Cardiac ischemia |
| 00–111 | BD | M | 70/35 | 4:50 | 43 | 02:45 | 10 | 6.26 | 1490 | 1 | Li, ZUC, valproate, BZD | Li, ECT | No | No | Cardiac arrest, ileus due to intestinal haemorrhage |
| 00-088b | BD | M | 73/45 | 5:15 | 36 | 09:30 | 7 | 6.38 | 1260 | 2 | Li, BZD, SSRI, Hal, ECT, MAOI, methylphenidate | Li, SSRI, Hal, methylphenidate | Yes | No | Cachexia, dehydration |
| 98-010 | BD | F | 75/20 | 4:00 | 38 | 20:45 | 1 | ND | 1123 | 1 | TeCA, TCA | BZD, TeCA, SSRI, Hal, Mo | No | No | Acute abdomen secondary to a perforation of stomach/intestines due to NSAIDs |
| 12-048 | BD | M | 81/15 | 6:40 | 60 | 20:00 | 5 | 6.70 | 1283 | 1 | Li, prednisolon | Li, BZD, amitriptyline, valproate | No | No | Legal euthanasia |
| 12-110 | BD | M | 87/10 | 3:15 | 53 | 23:00 | 10 | 6.39 | 1285 | 3 | BZD, valproate | BZD, Mo, valproate | No | No | CVA, pneumonia |
| Median | – | – | 76/20 | 5:50 | 44 | 15:30 | 6 | 6.51 | 1271 | – | – | – | – | – | – |
| 99-033 | CTR | F | 61 | 17:45 | 119 | 23:15 | 12 | ND | 1296 | 0 | None | None | – | – | Acute heart failure, gastric blood loss |
| 97-042 | CTR | F | 65 | 12:50 | 28 | 02:00 | 4 | 6.94 | 910 | 1 | None | Adrenalin | – | – | Cardiac arrest, pneumonia, pulmonary oedema |
| 99-101 | CTR | M | 69 | 19:15 | 41 | 03:30 | 8 | 6.40 | 1352 | 1 | None | βB, Hal, BZD | – | – | Pneumonia |
| 92-049 | CTR | M | 71 | 5:40 | 32 | 12:00 | 4 | 7.40 | 1250 | ND | None | None | – | – | Found death |
| 08-032 | CTR | M | 71 | 8:55 | 70 | 03:15 | 3 | 6.64 | 1520 | 2 | Mo | Mo | – | – | Pancreas carcinoma, rectum carcinoma with hepatic metastases |
| 98-104 | CTR | F | 74 | 7:25 | 31 | 09:50 | 7 | 6.95 | 1167 | 2 | BZD | BZD, βB | – | – | Necrosis of the intestines secondary to thrombosis |
| 95-106 | CTR | M | 74 | 8:00 | 60 | 13:00 | 11 | 6.75 | 1317 | 0 | None | Dopamine | – | – | Myocardial infarction |
| 06-028 | CTR | M | 76 | 19:35 | 27 | 20:00 | 4 | 6.50 | 1514 | 3 | None | None | – | – | Prostate carcinoma, cardiac arrest |
| 94-039 | CTR | M | 78 | 53 | 88 | 12:00 | 1 | ND | 1354 | ND | None | Nitroglycerine | – | – | Myocardial infarction |
| 99-116 | CTR | M | 78 | 4:20 | 43 | 16:15 | 9 | ND | 1310 | 0 | None | Mo, BZD | – | – | Pancreatic cancer |
| 95-006 | CTR | M | 81 | 8:25 | 28 | 04:45 | 1 | 6.70 | 1274 | 1 | None | ND | – | – | Cardiogenic shock |
| 00-022 | CTR | F | 83 | 7:45 | 34 | 21:00 | 2 | 6.52 | 1102 | 2 | Digoxin, methimazole | Digoxin, methimazole | – | – | Acute myocardial infarction |
| 09-075 | CTR | M | 88 | 7:00 | 44 | 02:25 | 10 | 6.76 | 1230 | 3 | Salbutamol, prednisolone, | Mo, Hal, goserelin | – | – | Cachexia and dehydration by rectum carcinoma and prostate carcinoma |
| 09-001 | CTR | M | 88 | 4:43 | 51 | 19:47 | 1 | 6.17 | 1418 | 2 | None | None | – | – | Gastro-intestinal bleeding |
| 08-105 | CTR | F | 89 | 3:52 | 58 | 12:10 | 12 | 7.30 | 1258 | 3 | prednisolone | Hal, digoxine, Mo | – | – | Pneumonia |
| 08-054 | CTR | F | 92 | 7:00 | 67 | 09:45 | 6 | 6.55 | 1230 | 1 | Digoxine, prednison | prednison | – | – | Acute death, probably pulmonary embolism |
| Median | – | – | 77 | 7:52 | 43 | 12:00 | 5 | 6.7 | 1285 | – | – | – | – | – | – |
| p-Value | – | – | 0.616 | 0.361 | 0.780 | 0.711 | 0.93 | 0.137 | 0.515 | – | – | – | – | – | – |
Note: βB, beta-blocker; Ba, barbiturate; BD, bipolar disorder; Braak stage, progression of pathological changes for Alzheimer's disease according to Braak and Braak, 1991; BW, brain weight; BZD, benzodiazepine; CSF, cerebrospinal fluid; CTD, clock time at death; CTR, control; CVA, cerebrovascular accident; ECT, electroshock treatment; F, female; FT(d), fixation time in days; F, female; Hal, haloperidol; Li, lithium; M, male; MAOI, monoamine oxidase inhibitor; MDD, major depressive disorder; Mo, morphine; MOD, month of death; NBB, Netherlands Brain Bank; ND, no data; None, no medication; NSAIDs, nonsteroidal anti-inflammatory drugs; PMD, postmortem delay; PTSS, posttraumatische stressstoornis; SSRI, selective serotonin reuptake inhibitor; TCA, tricyclic antidepressant; TeCA, tetracyclic antidepressants; ZUC, zuclopenthixol. a: Patient also be diagnosis with post traumatic stress syndrome. b: Patient also be diagnosis with old cerebrovascular accident mildly demanded.