Fig. 5.

Significant methylation results reported across the entire NR3C1 proximal promoter. Methylation results reported only for clinical outcomes that have been significantly associated with methylation status in at least one study. Diseases for which there have only been non-significant findings or for which the authors concluded that NR3C1 was not a likely biomarker are not included. First exon variants in red represent the proximal promoter region. ▼ or ▲ denote hypomethylation or hypermethylation, respectively. ↓ or ↑ arrows denote a correlation between observed methylation and decreased or increased NR3C1 expression levels, respectively. Methylation shown here represents either mean or CpG site-specific methylation, depending on the study method used, and arrows shown here are not meant to indicate methylation at specific CpG loci. Figure is not to scale.

*Mean methylation levels only reported across all 4 first exon promoters, and not within each promoter.