TABLE 1.
Summary of primary screen results
| Library | Total no. of compounds | No. cherry-pickeda | No. with >30% inhibition |
No. with 20–30% inhibition |
No. with <20% inhibition |
Hit rateb (overall) |
|---|---|---|---|---|---|---|
| CMLD | 5,208 | 61 | 4 | 30 | 27 | 0.19 |
| TimTec Actiprobe 5K | 5,000 | 39 | 9 | 9 | 21 | 0.10 |
| FDA/Bioactives | 5,233 | 37 | 15 | 6 | 16 | 0.12 |
| Microsource Spectrum | 2,000 | 28 | 16 | 5 | 7 | 0.12 |
| Total | 17,441 | 165 | 44 | 50 | 71 | 0.54 |
a
Compounds were cherry-picked by selection of any compounds whose percent inhibition at read 3 was ≥2 SD from the median (15% cutoff).
b
The hit rate represents the number of compounds with >20% inhibition out of the total number of compounds.