FIG 4 .

Eritoran treatment reduces cytokine storm and the levels of free radicals. (A) Heat map of serum cytokine levels in placebo- and eritoran-treated mice following normalization to mock levels, day 6 postinfection. (B to F) Serum levels of inflammatory mediators, including Th1-associated cytokines (B), Th2-associated cytokines (C), chemokines (D), cytokines associated with stem cell and progenitor differentiation and survival of T lymphocytes and NK cells (E), and reactive oxygen species/reactive nitrogen species (F). Average fold difference versus uninfected mice, mean values ± standard errors based on 5 mice per group (mock and eritoran) or 4 mice per group (placebo). *, P < 0.05 for eritoran compared to placebo. See also Table S1.