Table 4.

Assessment of autonomic function, heart rate

	Controls (n = 10)	RDEB (n = 11)	P-value
HR ratio induced by standing 1 min	1.09 ± 0.04	1.1 ± 0.3	0.7
HR ratio induced by standing 10 min	1.19 ± 0.04	1.1 ± 0.06	0.2
HR ratio induced by Valsalva	1.33 ± 0.1	1.33 ± 0.2	0.9
HR response to deep breathing (Δmax–min)	17.5 ± 4	16.7 ± 11	0.8

Heart rate (HR) responses to orthostatic testing, Valsalva manoeuvre, and deep breathing. No statistical difference was observed between RDEB patients and controls related with heart rate variations induced by any of the tests.