TABLE 4.
Source of breakpointsb | Drug | Drug code(s) | Isolate D-01, S. Typhimurium |
Isolate D-18, S. Derby |
Isolate D-59, S. Albany |
Isolate C-02, S. I 4,5,12: i:− |
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---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Genotype predicted by WGS | Phenotype based on COMPAN2F | Phenotype based on NARMs | Genotype predicted by WGS | Phenotype based on COMPAN2F | Phenotype based on NARMs | Genotype predicted by WGS | Phenotype based on COMPAN2F | Phenotype based on NARMs | Genotype predicted by WGS | Phenotype based on COMPAN2F | Phenotype based on NARMs | |||
A | Amikacin | AMI | S | S | — | S | S | — | S | S | — | S | S | — |
A | Amoxicillin-clavulanic acid (2:1 ratio) | AMC, AUG2 | S | NI | S | S | NI | S | R | NI | R | S | NI | S |
A | Ampicillin | AMP | R | NI | R | R | NI | R | R | NI | R | R | NI | R |
D | Azithromycin | AZI | S | — | S | S | — | S | S | — | S | S | — | S |
A | Cefazolin | FAZ | S | S | — | S | S | — | R | NI | — | S | S | — |
E | Cefovecin | FOV | S | S | — | S | S | — | R | R | — | S | S | — |
C | Cefoxitin | FOX | S | S | S | S | S | S | R | R | R | S | S | S |
C | Cefpodoxime | POD | S | S | — | S | S | — | R | R | — | S | S | — |
C | Ceftriaxone | AXO | S | — | S | S | — | S | R | — | R | S | — | S |
D | Ceftiofur | XNL, TIO | S | S | S | S | S | S | R | R | R | S | S | S |
A | Cephalothin | CEP | S | S | — | S | S | — | S | NI | — | S | S | — |
A | Chloramphenicol | CHL | R | R | R | S | S | S | S | S | S | S | S | S |
C | Ciprofloxacin | CIP | S | — | S | S | — | S | S | — | S | S | — | S |
C | Doxycycline | DOX | S | S | — | R | R | — | S | S | — | S | S | — |
A | Enrofloxacin | ENRO | S | S | — | S | S | — | S | S | — | S | S | — |
A | Gentamicin | GEN | S | S | S | S | S | S | S | S | S | S | S | S |
A | Imipenem | IMI | S | S | — | S | S | — | S | S | — | S | S | — |
C | Kanamycin | KAN | R | — | R | R | — | R | S | — | — | S | — | — |
A | Marbofloxacin | MAR | S | S | — | S | S | — | S | S | — | S | S | — |
C | Nalidixic acid | NAL | S | — | S | S | — | S | S | — | S | S | — | S |
D | Streptomycin | STR | R | — | R | R | — | R | S | — | S | R | — | R |
A | Sulfisoxazole | FIS | R | — | R | R | — | R | S | — | S | S | — | S |
A | Tetracycline | TET | R | — | R | R | — | R | S | — | S | S | — | S |
C | Ticarcillin | TIC | R | R | — | R | R | — | R | R | — | R | R | — |
B | Ticarcillin-clavulanic acid constant 2 | TIM2 | Sc | Rc | — | S | S | — | R | R | — | S | S | — |
A | Trimethoprim-sulfamethoxazole | SXT, COT | S | S | S | S | S | S | S | S | S | S | S | S |
S, susceptible to drug; R, resistant to drug; NI, no interpretation (panel's highest drug concentration was lower than drug's breakpoint); –, drug not available on that plate.
Breakpoints from the following sources were used for interpretation: CLSI M31-A3 (108) (A), CLSI VET01-S2E (109) (B), CLSI M100-S24 (110) (C), NARMS (114) (D), and EMA (115) (E).
Discrepancy between phenotype and predicted genotype.