TABLE 1.
Utility of MTBDRplus directly on 2-month sputa to detect 2-month culture positivitya
| Assay characteristic | No. for MTBDRplus directly on 2-month sputa/no. for reference method (detection of culturable M. tuberculosis in liquid culture in MGIT) (%, 95% CI) |
||
|---|---|---|---|
| All (n = 279) | HIV infected (n = 172) | HIV uninfected (n = 107) | |
| Sensitivity | 45/58 (78, 65–87) | 23/30 (77, 58–90) | 22/28 (79, 59–92) |
| Specificity | 177/221 (80, 74–85) | 118/142 (83, 76–89) | 59/79 (75, 64–84) |
| Positive predictive value | 45/89 (51, 40–61) | 23/47 (49, 34–64) | 22/42 (52, 36–58) |
| Negative predictive value | 177/190 (93, 89–96) | 118/125 (94, 89–98) | 59/65 (90, 81–97) |
a
Comparison of characteristics of direct MTBDRplus assay using 2-month sputa (for predicting 2-month culture conversion) and of reference method (liquid culture in MGIT), with stratification of the cohort by HIV-1 serostatus to assess the effect of HIV-1 serostatus on the utility of the test.