FIG 4.

Diagnostic power evaluation of miRNAs for discrimination between LL and TT patients using a subset of four miRNAs. (A) Principal component scores of TLDA expression data of miR-101, miR-196b, miR-27b, and miR-29c indicate separation between LL and TT groups. (B) Normalized eigenvectors were used to transform qRT-PCR data revealing a separation between the groups. (C) The first qRT-PCR-transformed score was evaluated in a ROC analysis after logistic regression revealing 83.3% sensitivity and 80% specificity with the cutoff of 0.58 and an AUC of 83.3% (95% CI, 55.7% to 100.0%) for discrimination of LL and TT patients. TLDA, TaqMan low-density array.