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. 2017 Apr 25;5:17002. doi: 10.1038/boneres.2017.2

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Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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A micro-CT analysis of the cortical bone of LV4. (a) The three-dimensional reconstitution images of the bone structure of LV4. The region of cortical porosity is highlighted in blue. (b, c) Cortical bone volume (Cv) and (b) cortical void volume (Vv/Cv) (c) of ventral cortical bone of LV4 are plotted against the administration regimen of TPTD. The data are shown as the means+s.d. (n=4 or 5). * Indicates P<0.05 vs vehicle of each administration frequency (analysis of variance with post hoc Dunnett’s test). V: vehicle control, L: 1.2 μg·kg⁻¹, M: 6 μg·kg⁻¹, H: 30 μg·kg⁻¹.