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. 2017 Apr 26;7:46741. doi: 10.1038/srep46741

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Copyright © 2017, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(a–c) pMHC functional potency versus TCR-pMHC 3D kinetics estimated with the surface plasmon resonance assay. (d–f) pMHC functional potency versus TCR-pMHC 2D kinetics estimated with the adhesion frequency assay. The data for the top row was adapted from refs ⁸,¹⁰, and data for the bottom row is based on ref. 10. Symbols correspond to the following ovalbumin-derived peptides (altered peptide ligands or APLs): ★, OVA; ⚪, A2; ×, G4; , E1; , V-OVA; , R4.

Inline graphic — (a–c) pMHC functional potency versus TCR-pMHC 3D kinetics estimated with the surface plasmon resonance assay. (d–f) pMHC functional potency versus TCR-pMHC 2D kinetics estimated with the adhesion frequency assay. The data for the top row was adapted from refs ⁸,¹⁰, and data for the bottom row is based on ref. 10. Symbols correspond to the following ovalbumin-derived peptides (altered peptide ligands or APLs): ★, OVA; ⚪, A2; ×, G4; , E1; , V-OVA; , R4.