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. 2017 Apr 26;7:46741. doi: 10.1038/srep46741

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Copyright © 2017, The Author(s)

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Top row, binding in three dimensions: (A) 3D diffusion/encounter, (B) rotation/orientation, and (C) molecular binding. Bottom row, the three binding steps in two dimensions: (D) 2D (membrane) diffusion/encounter, (E) rotation/orientation, and (F) molecular binding. The vertical line separates dimensional dependent and independent processes. The fundamental kinetic constants corresponding to each step in 3D and 2D have been included: , for diffusion/encounter, e⁺, e⁻ for rotation/orientation and k⁺, k⁻ for binding and unbinding, respectively. The fundamental kinetic constants are defined in Table 1.

Inline graphic — Top row, binding in three dimensions: (A) 3D diffusion/encounter, (B) rotation/orientation, and (C) molecular binding. Bottom row, the three binding steps in two dimensions: (D) 2D (membrane) diffusion/encounter, (E) rotation/orientation, and (F) molecular binding. The vertical line separates dimensional dependent and independent processes. The fundamental kinetic constants corresponding to each step in 3D and 2D have been included: , for diffusion/encounter, e⁺, e⁻ for rotation/orientation and k⁺, k⁻ for binding and unbinding, respectively. The fundamental kinetic constants are defined in Table 1.