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. 2017 Apr 26;7:46741. doi: 10.1038/srep46741

Figure 4. Observed and expected trend lines between T cell functional output and effective (AF assay-derived) and fundamental kinetic constants for the set of peptides used in Fig. 1.

Figure 4

The blue solid lines correspond to the effective kinetic constants, Inline graphic, Inline graphic, Inline graphic and Inline graphic, as determined with the AF assay and the SS model. The red lines correspond to the fundamental binding constants (k+, k and KA). A dashed red line indicates an uncertainty in the direction and magnitude of the shift corresponding to a given fundamental binding parameter, depending on whether Inline graphic is positive or negative and whether Inline graphic is relatively large or small. See details in Cases 1, 2 and 4.