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Summary of Tms of WT and Mutant BECN2 CCDs
| Beclin 2 CCD | T m (°C) |
|---|---|
| Wild type | 18.1 ± 0.7 |
| E173L | NDa |
| N187L | 42.6 ± 0.1 |
| A190L + Y215L | 27.2 ± 0.1 |
| A197L + E208L | 40.3 ± 0.3 |
| H211L | 30.4 ± 0.2 |
| Q222L | NDa |
| R243L | 27.3 ± 0.5 |
ND: Not determined.
The T m of these mutants could not be obtained because the melting process is not cooperative.
