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. Author manuscript; available in PMC: 2017 Apr 26.
Published in final edited form as: Cell Rep. 2017 Feb 21;18(8):1958–1969. doi: 10.1016/j.celrep.2017.01.069

Figure 5.

Figure 5

MAPK signal amplification promotes tumor initiation in AT2 and club cells. (a) KrasG12D/+;p53flox/flox;Rosa26LSL-YFP/+ mice were infected with Ad:SPC-Cre or Ad:CC10-Cre to initiate tumor formation. One-week post infection, control or PLX4720 treatments began and lung tissue was analyzed four weeks later. (b) Immunohistochemistry of serial lung sections for YFP and pErk. Scale bars are 50 microns. (c) Immunofluorescence for YFP (yellow). Scale bars are 100 microns. (d) Contingency tables of YFP-positive singlet cells from (c). Significance indicated, fisher’s exact test. Also see Figure S6.