Table 2.
Predictive selection model defined different bacterial composition in ME/CFS diagnostic groups
| Diagnostic groups Selected bacterial species |
In-sample | Cross-Validation | ||||
|---|---|---|---|---|---|---|
| AUC | AUC | ER (%) | FP (%) | FN (%) | ||
| ME/CFS (50) vs. control (50) | ||||||
| [Firmicutes] Coprococcus catus | ↓ | 0.831 | 0.684 | 36.72 | 40.00 | 33.43 |
| [Firmicutes] Pseudoflavonifractor capillosus | ↑ | |||||
| [Firmicutes] Dorea formicigenerans | ↓ | |||||
| [Firmicutes] Faecalibacterium prausnitzii | ↓ | |||||
| [Firmicutes] Coprococcus catus | ↓ | 0.893 | 0.745 | 29.68 | 29.71 | 29.64 |
| [Firmicutes] Pseudoflavonifractor capillosus | ↑ | |||||
| [Firmicutes] Dorea formicigenerans | ↓ | |||||
| [Firmicutes] Faecalibacterium prausnitzii | ↓ | |||||
| [Firmicutes] Clostridium asparagiforme | ↑ | |||||
| [Proteobacteria] Sutterella wadsworthensis | ↓ | |||||
| [Bacteroidetes] Alistipes putredinis | ↓ | |||||
| [Firmicutes] Anaerotruncus colihominis | ↑ | |||||
| ME/CFS + IBS (21) vs. control (50) | ||||||
| [Firmicutes] Faecalibacterium cf | ↓ | 0.771 | 0.571 | 33.09 | 18.57 | 69.38 |
| [Bacteroidetes] Bacteroides vulgatus | ↑ | |||||
| [Firmicutes] Faecalibacterium cf | ↓ | 0.923 | 0.687 | 25.59 | 18.43 | 43.48 |
| [Bacteroidetes] Bacteroides vulgatus | ↑ | |||||
| [Firmicutes] Faecalibacterium prausnitzii | ↓ | |||||
| [Bacteroidetes] Alistipes putredinis | ↓ | |||||
| [Firmicutes] Coprococcus catus | ↓ | |||||
| [Firmicutes] Faecalibacterium cf | ↓ | 1 | 0.791 | 24.31 | 18.28 | 39.40 |
| [Bacteroidetes] Bacteroides vulgatus | ↑ | |||||
| [Firmicutes] Faecalibacterium prausnitzii | ↓ | |||||
| [Bacteroidetes] Alistipes putredinis | ↓ | |||||
| [Firmicutes] Coprococcus catus | ↓ | |||||
| [Firmicutes] Anaerostipes caccae | ↑ | |||||
| [Firmicutes] Dorea formicigenerans | ↓ | |||||
| [Firmicutes] Anaerotruncus colihominis | ↑ | |||||
| [Firmicutes] Clostridium asparagiforme | ↑ | |||||
| ME/CFS w/o IBS (29) vs. control (50) | ||||||
| [Bacteroidetes] Bacteroides caccae | ↓ | 0.775 | 0.589 | 40.67 | 25.29 | 66.30 |
| [Firmicutes] Pseudoflavonifractor capillosus | ↑ | |||||
| [Bacteroidetes] Bacteroides caccae | ↓ | 0.948 | 0.754 | 28.41 | 21.07 | 40.65 |
| [Firmicutes] Pseudoflavonifractor capillosus | ↑ | |||||
| [Bacteroidetes] Parabacteroides distasonis | ↓ | |||||
| [Bacteroidetes] Bacteroides fragilis | ↑ | |||||
| [Bacteroidetes] Prevotella buccalis | ↑ | |||||
| [Bacteroidetes] Bacteroides xylanisolvens | ↑ | |||||
| [Firmicutes] Dorea formicigenerans | ↓ | |||||
| ME/CFS w/o IBS (29) vs. ME/CFS + IBS (21) | ||||||
| [Bacteroidetes] Bacteroides vulgatus | ↓ | 0.913 | 0.604 | 37.61 | 29.30 | 50.08 |
| [Bacteroidetes] Prevotella buccalis | ↑ | |||||
| [Firmicutes] Ruminococcus lactaris | ↑ | |||||
| [Firmicutes] Eubacterium hallii | ↑ | |||||
| [Firmicutes] Anaerotruncus colihominis | ↓ | |||||
| [Firmicutes] Faecalibacterium cf | ↑ | |||||
| [Firmicutes] Clostridium methylpentosum | ↑ | |||||
| [Bacteroidetes] Bacteroides vulgatus | ↓ | 0.956 | 0.604 | 41.51 | 27.32 | 62.80 |
| [Bacteroidetes] Prevotella buccalis | ↑ | |||||
| [Firmicutes] Ruminococcus lactaris | ↑ | |||||
| [Firmicutes] Eubacterium hallii | ↑ | |||||
| [Firmicutes] Anaerotruncus colihominis | ↓ | |||||
| [Firmicutes] Faecalibacterium cf | ↑ | |||||
| [Firmicutes] Clostridium methylpentosum | ↑ | |||||
| [Firmicutes] Faecalibacterium prausnitzii | ↑ | |||||
| [Proteobacteria] Klebsiella pneumoniae | ↓ | |||||
| [Bacteroidetes] Parabacteroides distasonis | ↓ | |||||
| [Bacteroidetes] Prevotella copri | ↑ | |||||
The arrows represent the increased or decreased relative abundance of bacterial species in total ME/CFS, ME/CFS + IBS, ME/CFS w/o IBS (compared to controls). In the last comparison, the arrow represents changes in the ME/CFS without IBS group (compared to ME/CFS with IBS). ME/CFS myalgic encephalomyelitis/chronic fatigue syndrome, IBS irritable bowel syndrome, AUC area under the curve, ER error rate, FP false positive, FN false negative