Fig. 5.

Relative six-minute walk test (6MWT) minimal clinically important difference (MCID) using Anchor-based methods. Sources: 3 = Swigris, 2010 [31]; 4 = Holland, 2009 [42]; 5 = Holland, 2010 [43]; 6 = Polkey, 2013 [32]; 8 = Puhan, 2011 [44]; 9 = Redelmeier, 1997 [45]; 11 = Lee, 2014 [46]; 15 = Mathai, 2012 [49]; 16 = Henricson, 2013 [28]; 18 = Kwok, 2013 [50]. The green, red, blue, and orange bars represent studies conducted in patients with respiratory, cardiovascular, muscular, and other (i.e., frail elderly) diseases, respectively. COPD: chronic obstructive pulmonary disease; IPF: idiopathic pulmonary fibrosis; PAH: pulmonary arterial hypertension