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. 2017 Apr 26;12:78. doi: 10.1186/s13023-017-0633-1

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Relative six-minute walk test (6MWT) minimal clinically important difference (MCID) using distribution-based methods. Sources: 1 & 2 = du Bois, 2010 [29] and du Bois, 2011 [30]; 3 = Swigris, 2010 [31]; 4 = Holland, 2009 [44]; 5 = Holland, 2010 [43]; 7 = Puhan, 2008 [51]; 8 = Puhan, 2011 [44]; 10 = Wise, 2005 [52]; 11 = Lee, 2014 [46]; 15 = Mathai, 2012 [49]; 17 = McDonald, 2013 [54]; 18 = Kwok, 2013 [50]. The green, red, blue, and orange bars represent studies conducted in patients with respiratory, cardiovascular, muscular, and other (i.e., frail elderly) diseases, respectively. COPD: chronic obstructive pulmonary disease; IPF: idiopathic pulmonary fibrosis; PAH: pulmonary arterial hypertension