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Dose modification
| Toxicity (grade) | Dose modification |
|---|---|
| ANC <1000/mm3 | Discontinue the treatment until ANC ≥1500/mm3; resume the treatment with the same dose |
| Platelets <50,000/mm3 | Discontinue the treatment until platelets ≥100,000/mm3; resume the treatment with the same dose |
| Other toxicities | No dose modification or interruption required |
| Grades 1 and 2 | Discontinue the treatment until returns to baseline; resume the treatment to 200 mg daily |
| Grades 3 and 4 |
