Table 3.

Univariable Cox’s proportional hazards regression analyses regarding transplantation-free survival in patients with pulmonary arterial hypertension (PAH)

Variable	Univariable Cox’s proportional hazards regression model
	HR	95% CI	p-value
Neutrophils, 106/ml	1.03	0.92–1.14	0.644
Neutrophils, %	1.06	1.02–1.1	0.002
Lymphocytes, 106/ml	0.37	0.17–0.83	0.016
Lymphocytes, %	0.22	0.90–0.99	0.022
Neutrophil/lymphocyte ratio	1.05	1.01–1.08	0.006
Eosinophils, > 0.1 106/ml	0.79	0.35–1.77	0.537
Age, years	1.01	0.98–1.04	0.454
Male gender	1.42	0.68–2.96	0.346
Prevalent vs. incident PAH	0.70	0.36–1.36	0.296
Idiopathic PAH vs. non-idiopathic PAH	2.17	1.11–4.24	0.023
WHO-FC	2.62	1.32–5.15	0.005
6WMD, >380 m	0.29	0.10–0.87	0.027
NT-proBNP, > 3474 ng/l	2.33	1.19–4.57	0.014
CRP > 5 mg/dl	2.05	1.04–4.05	0.039
GFR > 60 ml/min/1.73 m2	0.38	0.19–0.74	0.004
mPAP, mm Hg	1.02	0.99–1.04	0.142
Cardiac index, ml/min/m2	0.58	0.55–1.39	0.580
PVR, dyn*s*cm−5	1	1–1.01	0.13
RAP, mm Hg	1.06	0.99–1.14	0.108
SvO2, %	0.96	0.96–0.99	0.007
Arterial hypertension	0.78	0.39–1.54	0.470
Diabetes mellitus	0.76	0.27–2.17	0.618
Coronary heart disease	1.67	0.80–3.46	0.171
Atrial fibrillation	0.91	0.34–2.46	0.858
BMI ≥ 30 kg/m2	1.05	0.39–2.81	0.92
CVRF ≥ 3a	0.76	0.18–3.27	0.716
Chronic obstructive pulmonary disease	0.67	0.26–1.72	0.405

^aCVRF including arterial hypertension, diabetes mellitus, coronary heart disease, atrial fibrillation and body mass index

6MWD 6 minute walking distance, BMI body mass index, CI confidence interval, CRP C-reactive protein, CVRF cardiovascular risk factors, GFR glomerular filtration rate, HR hazard ratio, mPAP mean pulmonary arterial pressure, NT-proBNP N-terminal of the prohormone brain natriuretic peptide, PVR pulmonary vascular resistance, RAP right atrial pressure, SvO ₂ mixed venous oxygen saturation, WHO-FC World Health Organization functional class