Table 3.
Relationships between clinical features of patients and single SNPs
| Characteristics | Total | rs4633 C > T | rs4680 G > A | rs6269 A > G | rs4818 C > G | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CC | CT | TT | P | GG | GA | AA | P | AA | AG | GG | P | CC | CG | GG | P | ||
| n | 143 | 78 | 56 | 9 | 79 | 56 | 8 | 62 | 67 | 14 | 64 | 66 | 13 | ||||
| H&Y stageb | 2.0 ± 1.0 | 2.0 ± 1.5 | 2.0 ± 1.0 | 3.0 ± 0.5 | 0.007** | 2.0 ± 1.5 | 2.0 ± 1.0 | 2.8 ± 0.5 | 0.01* | 2.5 ± 1.0 | 2.0 ± 1.0 | 2.0 ± 0.8 | 0.07 | 2.5 ± 1.0 | 2.0 ± 1.0 | 2.0 ± 0.8 | 0.09 |
| Age onset (years)a | 59.2 ± 9.2 | 60.7 ± 9.2 | 57.5 ± 9.4 | 57.3 ± 5.6 | 0.01* | 60.7 ± 9.2 | 57.6 ± 9.4 | 56.8 ± 5.7 | 0.01* | 59. 5 ± 9.5 | 58.828.6 | 60.3 ± 10.6 | 0.80 | 59.6 ± 9. 5 | 58.6 ± 8.6 | 60.8 ± 10.9 | 0.89 |
| Disease duration (years)b | 6.0 ± 5.0 | 6.0 ± 4.0 | 6.0 ± 5.8 | 9.0 ± 7.5 | 0.005** | 6.0 ± 4.0 | 6.0 ± 6.0 | 8.5 ± 9.5 | 0.005** | 6.0 ± 5.3 | 6.0 ± 5.0 | 7.5 ± 7.3 | 0.73 | 6.0 ± 5.0 | 6.0 ± 5.0 | 8.0 ± 8.5 | 0.75 |
| LED (mg)a | 448.8 ± 327.4 | 386.2 ± 287.5 | 496.8 ± 358.0 | 693.2 ± 322.6 | 0.005** | 389.5 ± 287.2 | 497.7 ± 358.5 | 692.4 ± 344.8 | 0.007** | 475.3 ± 399.2 | 425.0 ± 241.7 | 445.5 ± 346.5 | 0.56 | 469.7 ± 396.5 | 435.0 ± 243.6 | 416.4 ± 342.2 | 0.59 |
| Wearing-off (yes, %) | 43 (30.1) | 18 (23.1) | 19 (33.9) | 6 (66. 7) | 0.008** | 18 (22. 8) | 20 (35.7) | 5 (65.1) | 0.009** | 20 (32.3) | 17 (25.4) | 6 (42.9) | 0.94 | 20 (31.3) | 18 (27.3) | 5 (38.5) | 0.87 |
| Dyskinesia (yes, %)b | 18 (12.6) | 7 (9.0) | 9 (16.1) | 2 (22.2) | 0.12 | 7 (8.9) | 9 (16.1) | 2 (25.0) | 0.09 | 8 (12.9) | 7 (10. 5) | 3 (21.4) | 0.76 | 8 (12.5) | 7 (10.6) | 3 (23.1) | 0.67 |
| UPDRS Part I score b | 2.0 ± 3.0 | 2.0 ± 3.0 | 3.0 ± 3.0 | 2.0 ± 3.0 | 0.92 | 2.0 ± 3.0 | 3.0 ± 3.0 | 2.0 ± 3.5 | 0.91 | 2.0 ± 3.0 | 2.0 ± 3.0 | 3.0 ± 3.0 | 0.41 | 2.0 ± 4.0 | 2.0 ± 3.0 | 3.0 ± 3.0 | 0.31 |
| UPDRS Part II score b | 8.0 ± 7.0 | 8.5 ± 9.0 | 8.0 ± 7.3 | 13.0 ± 10.0 | 0.002** | 8.0 ± 9.0 | 8.0 ± 6.8 | 13.0 ± 7.8 | 0.02* | 8.0 ± 7.0 | 8.0 ± 8.0 | 11.0 ± 7.3 | 0.48 | 8.0 ± 7.0 | 9.0 ± 7.0 | 9.0 ± 7.5 | 0.70 |
| UPDRS Part III score a | 24.7 ± 12.1 | 25.9 ± 11.9 | 21.8 ± 11.6 | 32. 8 ± 12.3 | 0.01* | 25.8 ± 11.9 | 22.4 ± 12.1 | 31.0011.9 | 0.06 | 25.3 ± 12.3 | 24.2 ± 12.1 | 24.6 ± 11.6 | 0.82 | 24.8 ± 12.3 | 24.4 ± 12.3 | 26.2 ± 10.3 | 0.96 |
| UPDRS Part IV score b | 3.0 ± 2.0 | 3.0 ± 2.0 | 2.0 ± 3.0 | 5.0 ± 3.0 | 0.10 | 3.0 ± 2.0 | 2.0 ± 3.8 | 4.5 ± 4.0 | 0.13 | 3.0 ± 4.0 | 2.0 ± 3.0 | 3.0 ± 2.0 | 0.98 | 3.0 ± 4.0 | 2.5 ± 3.0 | 3.0 ± 2.0 | 0.96 |
| UPDRS total scorea | 40.0 ± 17.7 | 41.0 ± 17.4 | 36.3 ± 16.5 | 54.8 ± 20.2 | 0.006** | 40.8 ± 17.3 | 37.1 ± 17.3 | 52.0 ± 19.7 | 0.04* | 40.7 ± 18.4 | 38.8 ± 17.4 | 42.6 ± 15.8 | 0.79 | 40.2 ± 18.8 | 39.0 ± 17.1 | 44.1 ± 15.5 | 0.81 |
| NMS scoreb | 6.0 ± 6.0 | 6.0 ± 6.0 | 6.0 ± 4.8 | 7.0 ± 9.5 | 0.60 | 6.0 ± 6.0 | 6.5 ± 4.8 | 6.5 ± 10.8 | 0.68 | 7.0 ± 6.3 | 6.0 ± 6.0 | 6.5 ± 5.5 | 0.57 | 7.0 ± 7.8 | 6.0 ± 5.3 | 6.0 ± 6.0 | 0.38 |
| HAMA scoreb | 4.0 ± 6.0 | 4.0 ± 6.0 | 5.0 ± 4.5 | 4.0 ± 14.0 | 0.48 | 4.0 ± 6.0 | 5.0 ± 4.8 | 4.5 ± 13.3 | 0.40 | 5.0 ± 6.0 | 4.0 ± 4.0 | 6.0 ± 7.0 | 0.85 | 5.0 ± 6.0 | 4.0 ± 4.0 | 6.0 ± 6.0 | 0.93 |
| HAMD scoreb | 3.0 ± 4.0 | 2.0 ± 5.0 | 4.0 ± 4.0 | 4.0 ± 6.0 | 0.40 | 2.0 ± 5.0 | 4.0 ± 4.0 | 3.0 ± 6.5 | 0.20 | 2.0 ± 6.3 | 3.0 ± 4.0 | 2.0 ± 3.8 | 0.14 | 2.0 ± 7.0 | 3.0 ± 4.0 | 2.0 ± 2.0 | 0.41 |
| MMSE scoreb | 28.0 ± 3.0 | 28.0 ± 3.0 | 28.0 ± 3.0 | 27.0 ± 4.0 | 0.49 | 28.0 ± 3.0 | 28.0 ± 3.0 | 27.5 ± 3.0 | 0.54 | 28.0 ± 3.0 | 28.0 ± 3.0 | 28.0 ± 3.5 | 0.12 | 28.0 ± 3.0 | 28.0 ± 3.0 | 28.0 ± 3.5 | 0.13 |
Data were analyzed with analysis of variance of factorial design with age and sex as covariates
Binary logistic regression model was used to analyze the relation between SNP and motor complication (wearing-off phenomenon and dyskinesia), with age and sex as covariates
*P < 0.05 **P < 0.01
aValues are expressed as the mean ± SD
bValues are expressed as the median ± IQ