Fig. 5.
Chronic administration of 100 mg/kg/day SAL significantly reduced the expressions of CaL α1C-subunit at protein and mRNA levels in cerebral arteries isolated from diabetic GK rats. Representative band was used to show the protein expressions of CaL channel in WKY, WKY + SAL, GK, and GK + SAL rats (a). Normalized band intensities of CaL α1C-subunit are shown as a percentage of the β-actin density (b). Relative mRNA of CaL α1C-subunit are shown as a percentage of the β-actin mRNA (c). WKY: control WKY rats, WKY + SAL: control WKY rats administrated with 100 mg/kg/day SAL, GK: diabetic GK rats, GK + SAL: GK rats administrated with 100 mg/kg/day SAL. Values are expressed as means ± SEM from 4 independent experiments, and each sample based on tissue pooled from 3 to 4 animals. *P < 0.05 vs. WKY rats and #P < 0.05 vs. GK rats