Fig. 6.

Constraints-based Modeling predicts disruption of redox homeostasis and rewiring of metabolic network for compensation. a Core network representation of C. violaceum metabolism (iDB149) with tryptophan, violacein pathway (using Escher; https://escher.github.io/) and tailored biomass composition. b Reconstruction statistics and subsystem classification. c - e NADH and NAD experimental values attained for the three different strains using three different substrates – Glucose, Pyruvate and Succinate. Mean ± S.D. for triplicate samples represented