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. 2017 Apr 26;11:51. doi: 10.1186/s12918-017-0427-z

Table 1.

Fitness costs of antibiotic resistance on multiple substrates

Growth Rates (hr−1) Time Lag (hr)
Metabolites WT + chl WT + str WT ChlR StrpR WT + chl WT + str WT ChlR StrpR
Glucose 0.00 0.00 0.71 0.21 1.80 3 9.5 2
Glucose-6-phosphate 0.09 0.01 1.08 0.77 2.23 3 3 2 3.5 2
Glyceraldehyde 3-phosphate 0.00 0.00 0.00 0.00 0.00
Fructose 1,6-bisphosphate 0.00 0.01 1.14 0.23 0.25 3 1.5 6 10
Fumarate 0.00 0.06 1.55 0.21 0.27 3 1.5 12 13.5
Maleic acid 0 d 0.00 0.60 0 a 0 c 1
D-Malic acid 0.08 0.01 0.67 1.89 0 b 2.5 15.5 1.5 0
Succinate 0.00 0.00 1.00 0 a 0 b 2.5
Oxalic acid 0.00 0.00 0.00 0.00 0.00
Oxoadipic acid 0.04 0.00 0.62 0 e 0 c 0 0
Malonic acid 0.11 0.03 1.08 0.45 0.17 2.5 2.5 1.5 2 18
Pyruvate 0.41 0.00 0.58 0 e 0 b 4 2.5
Citric acid 0.00 0.00 0.00 0.00 0.00
Isocitric Acid 0.46 0.00 1.31 0.32 0.32 10 3.5 3.5 12.5
L-Lactic acid 0.29 0.00 0.99 1.05 0.16 3 4.5 4.5 18
Ketoglutaric acid 0.15 0.09 0.19 0.24 0.04 0 0 3.5 0 21
L-Arabinose 0.00 0.00 0.88 0.54 0.29 3.5 3.5 13.5
Manose 6-Phosphate 0.18 0.00 1.08 0.98 1.68 3 2.5 3.5 2.5
Ribose 5-phosphate 0.28 0.00 0.86 0.33 0.18 2.5 2.5 6 6
3-phosphoglyceric acid 0.29 0.26 0.28 0.40 0.18 2 2 0 6 6
L-Tryptophan 0.00 0.00 0.53 0.23 1.92 2 2 2
L-Alanine 0.21 0.00 0.96 0.28 0.36 2.5 2.5 6 3.5
L-Valine 0.28 0.00 0.74 0.33 0.14 2 2 6 6
L-Aspartate 0.27 0.20 0.19 0.41 0.18 2.5 2.5 0 6 10
L-Glutamine 0.00 0.00 0.83 1.15 0.26 2.5 3.5 13
L-Glutamate 0.52 0.16 1.28 1.12 0.23 3 3 3 3 12.5
Mannitol 0.24 0.00 1.00 0.98 0.20 3 2 3.5 8.5
D-Sorbitol 0.24 0.00 0.58 0.40 0.25 12.5 2.5 6 9.5
Glycerol 0.00 0.00 0.78 0.28 1.99 2.5 9.5 2.5
L-Ascorbic acid 0.00 0.18 0.81 0.23 0.27 3 3 6 12
Luria bertani 0.00 0.00 0.47 0.37 1.69 3 3 1.5 3 3

Altered kinetic parameters represented as Growth Rates and Time lag for the three populations of C. violaceum (WT, ChlR and StrpR) on multiple micro-environment metabolites. Zero growth rates are represented in bold

at6 initial till 180 min

bt0 initial till 180 min

ct0 first 60 min

d3 to 18 h growth

egrowth after 24 h