. 2017 Apr 26;10:15. doi: 10.1186/s13041-017-0293-z

Table 2.

Summary of Preclinical Efficacy of Group II mGlu Receptor Ligands

	Positive Symptom Models	Negative Symptom Models	Cognition Models
mGlu _2/3 agonists
LY354740	Reduced NMDAR-HL [127, 226] No effect on AHL [226, 227] Reduced NMDAR antagonist-induced stereotypies [127, 128] No effect on apomorphine-disrupted PPI [227] Inhibited DOI-induced head twitches [228]	Reduced PCP-induced deficits in social interaction [229]	Reduced PCP-induced deficits in the discrete-trial delayed alternation (DTDA) task [127] Impaired performance in delayed matching to position (DMTP) and DNMTP tasks [143]
LY379268	Reduced NMDAR-HL and AHL [141, 226, 230] No effect on PCP- or AMP-disrupted PPI [141] Inhibited DOI-induced head twitches [228] Reduced prenatal restraint-induced HL/PPI deficits [231] Reversed postnatal isolation-induced HL/PPI deficits [232]	Reduced MK-801-increase in immobility in forced swim test (FST) [230] Attenuated MK-801-induced deficits in social interaction [233, 234] Rescued prenatal restraint-induced deficits in social interaction [231]	Reduced PCP-induced increase in errors, but not accuracy, in the 5-choice serial reaction time task (5CSRT) [235] Exacerbated PCP-induced deficits in 5CRST task [236] Rescued MK-801-induced deficits in NOR [234] Reversed postnatal isolation-induced deficits in NOR [232]
mGlu ₂ PAMs
LY487379	Reduced NMDAR-HL and AHL [141] Attenuated AMP but not PCP-disrupted PPI [141]	Reduced PCP-induced deficits in social interaction [229]	Promoted cognitive flexibility in attentional set-shift task (ASST) [237]
BINA	Reduced NMDAR-HL [149, 230] No effect on AHL [149] Reduced PCP-disrupted PPI [149] Reduced DOB-induced head twitches [150]	Reduced MK-801-induced increased immobility in the FST [230]
TASP0443294	Reduced MHL [156]	Rescued MK-801 induced social memory deficits [156]
JNJ-40411813/ADX71149	Reduced NMDAR-HL [158] No effect on AHL [158] Inhibited DOM-induced head twitches [158]
SAR218645	No effect on NMDAR-HL or AHL [160] No effect on hyperactivity in DAT^−/− and NR1^neo−/− mice [160] Reduced DOI-induced head twitches [160]		Reversed MK-801-induced deficits in NOR [160] Attenuated working memory deficits in Y-maze test in NR1^neo−/− mice [160]