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| Basic Temperament | Stable – Hyperthymic | Unstable – Complex Cyclothymic |
|---|---|---|
| Sequence | MDI | DMI |
| Cyclicity | Endogenous | Exogenous |
| Evolution | Episodic, free intervals | Instability, tendency to rapid cycling |
| Reactivity to treatment | Prophylactic effect of lithium via attenuating hyperthymia | Worsening effect of antidepressants (formation of rapid cycling; chronic mixed state; mood switching) |
