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. 2016 May;10(2):83–90. doi: 10.2174/1872312810666160223121836

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© 2016 Bentham Science Publishers

This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

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Fig. (2) — Binning of 456 compounds into four quadrants based on their rat S9 and hepatocyte stability (Panel A) and human S9 and hepatocyte stability (Panel B). ● = Compound with good S9 and hepatocyte stability (rat = 185 compounds; human = 300 compounds). ♦ = Compound with poor S9 and hepatocyte stability (rat = 132 compounds; human = 84 compounds). ▲ = Compound with good S9 stability but poor hepatocyte stability (rat = 49 compounds; human = 24 compounds). ■ = Compound with poor S9 stability but good hepatocyte stability (rat = 90 compounds; human = 48 compounds).