Fig. (4).

Binning of compounds based on rat plasma clearance prediction by rat hepatocyte metabolic stability (Panel A; N = 223 compounds) or rat S9 metabolic stability (Panel B; N = 269 compounds) data. The metabolic stability and rat plasma clearance cutoff’s were at 70% remaining at 60’ and 43 mL/min/kg, respectively [7]. True positive = Compound with good stability and low plasma clearance. True negative = Compound with poor stability and rapid plasma clearance. False positive = Compound with good stability but rapid plasma clearance. False negative = Compound with poor stability but low plasma clearance.