Table 1.

7-EC and its metabolites generated in both rat and human microsomes, S9 fractions, and hepatocytes. Metabolically the S9 fractions are more representative of the hepatocytes than microsomes; phase I metabolite 7-HC is present in all three systems in both species, however phase II metabolites 7-HC glucuronide and 7-HC sulfate are only present in S9 and hepatocyte.

	Rat
Compound	Microsome		S9	Hepatocyte
7-HC	✓		✓	✓
7-HC Glucuronide			✓	✓
7-HC Sulfate			✓	✓
	Human
Compound	Microsome	S9		Hepatocyte
7-HC	✓	✓		✓
7-HC Glucuronide		✓		✓
7-HC Sulfate		✓		✓