Table 1.

Clinical characteristics of the 14 patients with therapy-related myeloid neoplasms (t-MNs). UID indicates de-identified unique patient identification number.

UID	Age at primary cancer	Gender	Primary Cancer	Chemotherapy	Radiation therapy	Latency to t-MN (years)	Age at t-MN	t-MN diagnosis	Cytogenetics in t-MN bone marrow
UID12766	55	Male	Colon adenocarcinoma	5-FU, Oxaliplatin	-	4	59	t-AML	Normal
UID984	63	Male	Esophageal adenocarcinoma	5-FU, Docetaxel	50 Gy	7	70	t-MDS	46~47,XY,+X,del(7)( q11.2),r(7),add(9)(q12)
UID10164	50	Female	Malignant peripheral nerve sheath tumor	Doxorubicin, Ifosphamide	-	1	51	t-MDS	46,XX,+1,der(1;7)(q10;p10)
UID6982	70	Male	Small Cell Lung Cancer	Cisplatin, Etoposide	70 Gy	3	73	t-AML	46,XY,del(5)(q15q33)
UID488	47	Female	NSCLC	Carboplatin, Paclitaxel, Gemcitabine, Vinorelbine	50 Gy	8	55	t-MDS	Normal
UID36491	62	Male	Small cell lung and NSCLC	Cisplatin, Etoposide, Carboplatin, Paclitaxel	70 Gy	4	66	t-MDS	42,X,-Y,del(1)(q21),del(7)(q 22q34),del(14)(q12q21),−16,−18,−21,−22,− 22,
UID4473	44	Male	Rectal adenocarcinoma	Capecitabine	50 Gy	6	50	t-MDS	Normal
UID17285	69	Male	Hodgkin lymphoma	Doxorubicin, Bleomycin, Vinblastine, Dacarbazine	-	2	71	t-MDS	45,XY,add(2)(p12),−5,−7,t(11;17)(q13;p11.2),+mar
UID19684	63	Male	Follicular lymphoma	Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, Prednisone	-	3	66	t-MDS	46,XY,−7,+22
UID7394	74	Male	Penile Squamous cell cancer	Paclitaxel, Ifosphamide, Cisplatin, Capecitabine	65 Gy	3	77	t-MDS	46,XY,del(5)(q13q33), 46,XY,der(3;5)(q10;p10),+8
UID49278	63	Male	Lung adenocarcinoma	Carboplatin, pemetrexed	66 Gy	1	64	t-AML	45,X,-Y
UID12484	64	Male	Mantle Cell Lymphoma	Bortezomib, Rituximab, Cyclophosphamide, Vincristine, Doxorubicin, Cytarabine, Methotrexate, Ibrutinib	-	2	66	t-AML	45,XY,der(7;17)(p10; q10)
UID19304	25	Female	Gliobastoma multiforme	Temozolamide	60 Gy	3	28	t-MDS	46,XX,inv(3)(q21q26.2)
UID31000**	40	Male	Rhabdomyos arcoma	Ifosphamide, Adriamycin	50 Gy	3	43	t-AML	44,XY,del(5)(q13),add(7)(q11.2),−11,−12,−17,−17,+r,+mar

^*UID: Unique patient ID,

NSCLC: Non small cell lung cancer, t-MN: therapy-related myeloid neoplasms.

^**The case was later confirmed to have Li-Fraumeni Syndrome