Figure 1.

Phosphotyrosine writers and erasures during mitosis. (A) During early mitosis, retraction of actin-rich focation adhesiosn results in retraction -like fibers which may be regulated by the PTPRF phosphatase. (B) During mitosis, the Src Family Kinases (SFKs), and the CDC14A phosphatase contribute to proper spindle formation. SFKs and th ABL kinase have also both been implicated in spindle positioning and spindle orientation, whereas DUSP23 may regulate centriole biogenesis in S- phase thereby contributing to spindle bipolarity. (C) DSUP19 is thought to regulate the duration of anaphase whereas SFKs may play a role in cytokinesis.