Figure 4.

Altered expression levels of EZH2 and KDM in MRI-classified group I/II GBM independent of IDH mutation. (A) All GBM specimens used in this study are negative for IDH mutation as shown in representative GBM at right panel. (B) In addition to IDH mutation, other metabolic influx from folate cycle or amino acid metabolism can fluctuate the levels of methyltransferases or demethylases. (C) Scatter plot indicating expression fold changes of chromatin modifiers present in gene list common to group I/II GBM. Scale of X- and Y-axes are in units log2(fold change GBM I/II / control). Point colors are grouped by whether differential gene expression increased or decreased in either case of GBM. Size of points is equal to the sum of absolute values of expression values for group I/II GBM (i.e., | fold change GBM I | + | fold change GBM II |). Genes that have values of log2(fold change) ≥ 1 or ≤ −1 in both group I/II GBM are highlighted in red.