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. Author manuscript; available in PMC: 2018 May 1.
Published in final edited form as: Biomaterials. 2017 Feb 17;125:65–80. doi: 10.1016/j.biomaterials.2017.02.020

Figure 1. Design and protein release kinetics of coacervate-fibrin gel composite.

Figure 1

(A) The release system was comprised of a fibrin gel embedding TIMP-3 aimed for early release; and FGF-2/SDF-1α-loaded coacervates distributed within the same gel aimed for late release. The coacervate was formed through electrostatic interactions by combining FGF-2 and SDF-1α with heparin then with PEAD polycation. (B) The cumulative release plot of the proteins shows the total percentage amount of each protein released with time. The plot shows quick release of TIMP-3 by 1 week followed by a sustained release of FGF-2 and SDF-1α up to 6 weeks. Data are presented as means ± SD (n=3).