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. Author manuscript; available in PMC: 2017 Jun 7.
Published in final edited form as: J Am Coll Cardiol. 2016 Apr 3;67(22):2578–2589. doi: 10.1016/j.jacc.2016.03.520

Figure 3. Cumulative LDL cholesterol Exposure in Familial Hypercholesterolemia Mutation Carriers Compared on Non-carriers Matched on LDL cholesterol at Ascertainment.

Figure 3

Hypercholesterolemic [low-density lipoprotein (LDL) cholesterol ≥ 130 mg/dl] carriers of a familial hypercholesterolemia (FH) mutation were identified in the Atherosclerosis Risk in Communities (ARIC) and Framingham Heart Study (FHS) Offspring cohorts and matched 1:1 to a FH mutation non-carriers according to age, gender, statin use, and LDL cholesterol at time of ascertainment. Mean ± standard error (SE) LDL cholesterol values at each study visit are displayed in each cohort according to mutation status. A matched pairs t-test demonstrated higher cumulative exposure to LDL cholesterol in FH mutation carriers versus non-carriers.