Table 3.
Frequency of the genotype and alleles of tested single nucleotide polymorphisms (SNPs) of secretoglobin family 3A member 2 (SCGB3A2) gene in the control group and the asthma group.
| SNP | Type | Control n (%) |
Asthma n (%) |
Model | OR (95% CI) | p |
|---|---|---|---|---|---|---|
| rs6882292 | G/G | 345 (91.5) | 82 (81.2) | Dominant | 2.66 (1.42–5.01) | 0.0033 |
| Promoter | G/A | 31 (8.2) | 19 (18.8) | Recessive | 0.00 (0.00–NA) | 0.48 |
| −659, G/A | A/A | 1 (0.3) | 0 (0.0) | Log-additive | 2.45 (1.33–4.54) | 0.0055 |
| G | 721 (95.6) | 183 (90.6) | 1 | |||
| A | 33 (4.4) | 19 (9.4) | 2.27 (1.26–4.08) | 0.006 | ||
| rs1368408 | G/G | 223 (59.1) | 49 (48.5) | Dominant | 1.59 (1.02–2.49) | 0.041 |
| Promoter | G/A | 143 (37.9) | 44 (43.6) | Recessive | 3.02 (1.15–7.90) | 0.03 |
| −112, G/A | A/A | 11 (2.9) | 8 (7.9) | Log-additive | 1.63 (1.12–2.37) | 0.012 |
| G | 589 (78.1) | 142 (70.3) | 1 | |||
| A | 165 (21.9) | 60 (29.7) | 1.51 (1.07–2.14) | 0.021 |
SNP – singe nucleotide polymorphism; OR – odds ratio; CI – confidence interval; n, number of subjects. The P values were calculated using logistic regression analyses, adjusting for the sex and age. Numbers in bold font indicate significant associations.