Table 4.
Responsiveness values of the NHPT.
| Study | N | Sample characteristics | Distribution-based method | Anchor-based method |
|
|---|---|---|---|---|---|
| Clinician’s perspective | Patient perspective | ||||
| De Groot et al.32 | 156 | Mean age: 37.6 years | Anchors: EDSS, GRS | Anchor: EDSS | Anchor: GRS |
| Mean EDSS: 2.5 | SRCind = 5.32 EDSS | AUC = 0.67 (0.58–0.76) | AUC = 0.59 (0.49–0.69) | ||
| Mean disease duration 0.26 years | SRCgr = 0.53 | − | − | ||
| Mean ± SD NHPT = 21.1 ± 4.0 | SRCind = 2.82 GRS | ||||
| SRCgr = 0.55 | |||||
| Kierkegaard et al.18 | 164 | Mean age: 51 years | Anchors: Katz P-ADL and I-ADL | Anchor: FAI | |
| EDSS: between 1 and 9 | AUC = 0.94 (0.91–0.97) | AUC = 0.85 (0.79–0.91) | |||
| Mean NHPT score was not reported | Cut-off value = 0.35 pegs/s | Cut-off value = 0.48 pegs/s | |||
| AUC = 0.87 (0.81–0.92) | |||||
| Cut-off value = 0.52 pegs/s | |||||
NHPT: Nine-Hole Peg Test; SD: standard deviation; EDSS: Expanded Disability Status Scale; GRS: Global Rating Scale; Katz P-ADL: Katz Personal ADL; Katz I-ADL: Katz Instrumented ADL; FAI: Frenchay Activity Index; AUC: area under the receiver operating characteristic curve (values: 95% confidence interval); MIC: minimally important change; SRCind: smallest real change at individual level; SRCgr: smallest real change at group level.