Table 1. Skin temperature (mean ± SD) in cats after saline (SAL) or buprenorphine administration via the three treatment routes: Intravenous (IV), subcutaneous (SC), and buccal (OTM).

	Route	Time (hours)
		0	0.5	1	2	4	6	8	12	24	30	36	48	60	72
Variable ST (°C)	SAL (n = 6)	36.3 ± 0.4	36.4 ± 0.3	36.5 ± 0.1	36.2 ± 0.2	36.2 ± 0.2	36.3 ± 0.2	36.3 ± 0.3	36.4 ± 0.3	36.5 ± 0.2	36.5 ± 0.5	36.6 ± 0.4	36.4 ± 0.4	36.4 ± 0.3	36.4 ± 0.3
	IV (n = 6)	37.3 ± 0.5*	37.4 ± 0.8*	37.8 ± 0.5*	37.5 ± 0.7*	37.7 ± 0.5*	37.4 ± 0.3*	37.2 ± 0.2*	37.5 ± 0.6*	37.2 ± 0.4	36.9 ± 0.3	37.2 ± 0.3	37.1 ± 0.4*	37.1 ± 0.3*	36.8 ± 0.4
	SC (n = 6)	37.0 ± 0.3*	37.1 ± 0.6	37.7 ± 0.4†*	37.5 ± 0.5*	37.6 ± 0.8†*	37.6 ± 0.5*	37.6 ± 0.8†*	37.6 ± 0.4†*	37.3 ± 0.5*	37.1 ± 0.5	37.2 ± 0.6	37.0 ± 0.3	37.1 ± 0.2	37.1 ± 0.4*
	OTM (n = 6)	37.2 ± 0.4*	37.4 ± 0.5*	37.7 ± 0.3*	37.4 ± 0.3*	37.5 ± 0.4*	37.4 ± 0.4*	37.1 ± 0.3*	37.0 ± 0.5	37.2 ± 0.2	37.1 ± 0.3	37.1 ± 0.4	37.2 ± 0.3*	37.3 ± 0.5*	37.3 ± 0.4*

ST (Skin Temperature); SAL (Saline SC); IV (0.12 mg kg^-1 buprenorphine IV); SC (0.24 mg kg^-1 buprenorphine SC); OTM (0.12 mg kg^-1 buprenorphine buccal route of administration).

^† Significant difference from baseline values.

* Significant difference from saline treatment (Two-way ANOVA).