Table 2. Thermal threshold (mean ± SD) in cats after saline (SAL), or buprenorphine administration via the three treatment routes: Intravenous (IV), subcutaneous (SC), and buccal (OTM).
| Route | Time (hours) | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 0 | 0.5 | 1 | 2 | 4 | 6 | 8 | 12 | 24 | 30 | 36 | 48 | 60 | 72 | ||
| Variable TT (°C) | SAL (n = 6) | 43.8 ± 2.1 | 44.7 ± 2.7 | 44.2 ± 2.8 | 43.8 ± 1.3 | 43.5 ± 2.0 | 43.5 ± 2.0 | 43.8 ± 2.4 | 44.0 ± 2.2 | 44.2 ± 2.2 | 44.0 ± 2.5 | 45.0 ± 3.3 | 44.6 ± 1.8 | 43.8 ± 1.7 | 44.0 ± 1.8 |
| IV (n = 6) | 45.7 ± 1.8 | 50.3 ± 3.7†* | 49.6 ± 2.4†* | 50.2 ± 3.3†* | 49.9 ± 2.0†* | 48.9 ± 5.0* | 50.2 ± 5.0†* | 46.4 ± 2.2 | 48.5 ± 4.4 | 46.2 ± 2.2 | 46.7 ± 2.5 | 45.1 ± 1.9 | 45.7 ± 2.4 | 46.7 ± 2.6 | |
| SC (n = 6) | 45.6 ± 1.1 | 49.4 ± 2.3 | 49.7 ± 4.1†* | 49.2 ± 3.1* | 50.2 ± 4.6†* | 50.9 ± 3.7†* | 51.1 ± 4.2†* | 49.7 ± 3.1†* | 49.7 ± 3.3†* | 49.3 ± 3.2* | 49.0 ± 2.8 | 48.0 ± 4.0 | 45.1 ± 1.7 | 45.8 ± 1.6 | |
| OTM (n = 6) | 46.1 ± 1.6 | 49.3 ± 4.8 | 49.5 ± 4.8†* | 51.2 ± 3.9†* | 50.5 ± 3.7†* | 48.6 ± 4.2* | 50.4 ± 4.3†* | 49.4 ± 3.8* | 47.7 ± 2.2 | 46.8 ± 1.3 | 47.1 ± 1.2 | 46.0 ± 1.2 | 46.7 ± 1.4 | 46.4 ± 1.2 | |
TT (Thermal threshold); SAL (Saline SC); IV (0.12 mg kg-1 buprenorphine IV); SC (0.24 mg kg-1 buprenorphine SC); OTM (0.12 mg kg-1 buprenorphine buccal route of administration).
† Significant difference from baseline values.
* Significant difference from saline (Two-way ANOVA).