. 2017 Apr 26;12(4):e0176443. doi: 10.1371/journal.pone.0176443

Table 4. Median pharmacokinetic estimates using high doses of buprenorphine by different routes of administration in cats.

Parameter	Units	Current Study	Taylor et al. 2015
Dose	μg kg^-1	120–240	20	60	120	240
Route		All routes	SC	SC	SC	SC
Clearance or CL/F	L kg^-1 hour^-1	0.98	-	1.0	0.92	0.94
V_{D-Steady State}	L kg^-1	7.9	-	0.58^*	0.59^*	0.66^*
Elimination Half-life	Hour	12.3	2.7	22.4	19.7	17.2

Values converted from published estimates to standardize units, Subcutaneous (SC),

*Vdbeta/F (L/mL)