Fig 1. Plot of the association in the KNG1 locus with plasma FXI levels.

Markers represented common variants organized by genomic position. The diamond-shaped marker represented the top SNP (rs710446) which was still statistically significantly associated after adjustment for multiple testing. The left axis shows the statistical significance of the variant-plasma FXI level variation association expressed as -log₁₀ of the p-values and colour intensities show the level of linkage disequilibrium between all variants and the top SNP. The recombination rate in the HapMap II sample [33] for this region is measured on the right axis.