Fig 3. Plot of the collapsing method association in the KNG1 locus with plasma FXI levels.

Markers represented the mean position of low-frequency variant sets. All of the markers located above the dotted horizontal line obtained a p-value <0.05 after the collapsing method association. Diamond-shaped markers represented the five significant low-frequency variant sets with controlling FWER = 0.05. The biggest diamond-shaped marker is the top low-frequency variant set.