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. 2017 Apr 26;12(4):e0176245. doi: 10.1371/journal.pone.0176245

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© 2017 Yang et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 5 — Wild type and variant SIRT2 gene promoters were cloned into reporter gene vector pGL3 and transfected into HEK-293 cells. The transfected cells were collected and dual-luciferase activities were assayed. Empty vector pGL3-basic is used as a negative control. Transcriptional acitivity of the wild type SIRT2gene promoter was designed as 100%. Relative activities of SIRT2 gene promoters were calculated. Lanes 1, pGL3-basic; 2, pGL3-WT; 3, pGL3-38900907G; 4, pGL3-38900888_91del; 5, pGL3-38900562T; 6, pGL3-38900413C; 7, pGL3-38900291G; 8, pGL3-38900270G; 9, pGL3-38900030A; 10, pGL3-38899925C; 11, pGL3-38899903C; 12, pGL3-38899853T; 13, pGL3-38899852T; 14, pGL3-38899781G. WT, wild type. *, P<0.05; **, P<0.01.